Bionanoscience and Biochemistry laboratory

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Natural Nanomachine Research

Understanding enzymes such as DNA gyrase will help us to build artificial versions and to design new drugs such as antibiotics.

Protein Nanoscience Research

Designing and building new protein superstructures will allow new kinds of drug delivery system and ultimately, new kinds of nanoscale biological machines to be constructed.

DNA Nanoscience Research (FNP TEAM Project)

We are trying to build designed, programmable DNA structures using the DNA origami technique.

Latest News

15 Jun/2022

New PhD position available: Help fight antimicrobial resistance!

The Bionanoscience and Biochemistry laboratory is recruiting a doctoral student for a fully-funded position with a duration of up to three years. The successful candidate will work on an NCN-funded project entitled “Structural basis of transmissible fluoroquinolone resistance” to uncover the mechanisms of transmissible fluoroquinolone resistance in Mycobacterium tuberculosis. While working on the project, you […]

2 Jun/2022

Unano consortium aims to build bio-nanomachines

Our new una_europa funded project is a consortium of leading across europe aiming to build functional, biological nanomachines. Our new website just launched: www.unano.org

29 May/2022

New movie of “impossible” protein cages

We made a little movie : https://www.youtube.com/watch?v=WhT3hj6akEY&t=19s Based on our recent paper where we expanded the space of potential protein nanocages that can be made by realising that the flexibility of proteins means that they can form cages which, while mathematically impossible, can form and appear almost perfectly regular. Hopefully this will expand the possibilities […]

13 May/2022

New paper show how a tiny change can have a big impact on artificial protein nanostructures

We have shown that they can cause a nano-sized spherical protein cage to undergo a major change in shape simply by changing a single amino acid. The work is interesting as it provides insight into how artificial protein containers can be engineered and molded into different shapes for different applications. It also is of interest […]

Our Projects

We are very grateful to our funders including the Foundation for Polish Science, The National Science Centre and Una Europa. For more about the individual projects and funding. See our projects page.

About us

A bright amibtious team working on cutting-edge science across disciplines

Bionanomachines are fascinating nanoscale machines made from biological molecules, typically proteins, lipids, RNA and DNA. In nature they carry out an amazing array of tasks from copying your DNA to converting light into energy. In our lab we are interested in understanding, designing and building natural and artificial bionanomachines.

We use a mixture of biochemical, structural and computational techniques plus the most important ingredient: imagination. Currently we are particularly interested in the natural machine DNA gyrase both because of its fascinating and intricate mechanism but also because it is an important target for development of new antibacterial drugs.

We are also building artificial structures from proteins and DNA with the aim of developing Programmable Biological  Matter. This describes artificial nanoscale biological material which can be programmed to move on demand. This will be useful for new materials and particularly medical use for example in effective vaccines and smart drug delivery systems which may one day be used as effective disease treatments in particular for age-associated diseases.


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