Bionanoscience and Biochemistry laboratory

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Natural Nanomachine Research

Understanding enzymes such as DNA gyrase will help us to build artificial versions and to design new drugs such as antibiotics.

Protein Nanoscience Research

Designing and building new protein superstructures will allow new kinds of drug delivery system and ultimately, new kinds of nanoscale biological machines to be constructed.

DNA Nanoscience Research (FNP TEAM Project)

We are trying to build designed, programmable DNA structures using the DNA origami technique.

Latest News

14 Nov/2021

Heddle lab demonstrates DNA Topogami, a new kind of DNA origami

In new paper just published online we showed that by topologically linking together two DNA single-stranded scaffolds we could subsequently assemble two DNA origami shapes that were topologically linked together. This is a very stable link as a strand of DNA has to be cleaved (covalent bond breakage) to unlink the individual DNA origamis. We […]

15 Sep/2021

Artificial protein nanocages deliver into cells in latest Biomacromolecules publication

In a breakthrough piece of research, we have developed a tiny, hollow protein sphere, termed a “nanocage”, placed another protein inside it, and delivered both to cells. This uses our TRAP-cage technology. Well done to the team! go to the Biomacromolecules article

1 Sep/2021

Latest article on the cover of Science Advances!

Bacterial species are under continuous warfare with each other for access to nutrients. To gain an advantage in this struggle, they produce antibacterial compounds that target and kill their competitors. Different species of bacteria, including ones that live inside us, can battle each other for scarce resources using a variety of tactics. In our latest […]

6 Jan/2021

NAR paper on gyrase published!

Our paper showing how DNA-mimcking proteins are able to interact with gyrase to give protection against anntibacterial drugs was just publisehd in NAR. Congratulations to Łukasz Mazurek, Dmitryh Ghilarov and the whole team.

24 Sep/2020

BioRrxiv preprint published on pentapeptide protein mechanism of action on gyrase!

We just deposited a nice paper on pentapeptide repeat proteins. The paper shows how these DNA-mimcking proteins are able to interact with gyrase to give protection against anntibacterial drugs. To download the manuscript go to bioRxiv

1 Sep/2020

PhD position available!

The Heddle lab is excited to announce a new PhD position due to start from October 2020 or later. This is part of a new NCN “Maestro” grant to design and build novel artificial protein cages. If you are interested in doing your PhD in synthetic structural biology with us please see instructions here and also contact the lab […]

About us

A bright amibtious team working on cutting-edge science across disciplines

We are an ambitious lab. Individual researchers work on a variety of topics and with a wide range of expertise. We are always learning from each other and work together as a team.

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