The Bionanoscience and Biochemistry laboratory is recruiting a doctoral student for a fully-funded position with a duration of up to three years. The successful candidate will work on an NCN-funded project entitled “Structural basis of transmissible fluoroquinolone resistance” to uncover the mechanisms of transmissible fluoroquinolone resistance in Mycobacterium tuberculosis. While working on the project, you will use cryo-electron microscopy to study the interactions of fluoroquinolone resistance protein MfpA with Mycobacterial DNA gyrase. The project offers an opportunity to carry out basic molecular biology research (DNA topoisomerase biology) with a real-world impact (antimicrobial drug resistance). You will learn relevant techniques of protein production and structural biology techniques, particularly cryo-EM. You will also have the opportunity to participate in silico drug design, screening and activity testing. More information about the Bionanoscience and Biochemistry laboratory is available under the link here
For the details of the competition and required documentation go to the website of Doctoral School of Exact and Natural Sciences at the Jagiellonian University here or contact the Bionanoscience and Biochemistry Laboratory directly.
