In new paper just published online we showed that by topologically linking together two DNA single-stranded scaffolds we could subsequently assemble two DNA origami shapes that were topologically linked together. This is a very stable link as a strand of DNA has to be cleaved (covalent bond breakage) to unlink the individual DNA origamis. We hope this could be useful for making multi-domain, stable DNA origami machines. Click here to read the work which was published in ACS Nanoscience Au.
